San Francisco 49ers offensive guard Daniel Brunskill, center, protects quarterback Nick Mullens, right, during the second half against the Los Angeles Rams on Sunday in Inglewood, Calif. (AP photo)

The San Francisco 49ers are set to embark on an unusual three-week road trip after being kicked out of their stadium and practice facility because of strict new COVID-19 protocols in their home county.

The Niners were set to fly to Arizona today where they will practice, live and play their next two games after Santa Clara County imposed a three-week ban on games and practices for contact sports.

The new rules that went into effect Monday and will last until at least Dec. 21 were announced Saturday as the Niners were preparing to fly to Los Angeles for a game against the Rams. The team scrambled to make new arrangements and settled on Arizona.

“You always expect bumps in the road no matter what you’re doing,” coach Kyle Shanahan said Tuesday. “The biggest bump was just the shock of finding out how long it was a day before we played. That was the biggest thing. I think our guys are pretty good … once they hear the parameters of stuff and adjusting and just dealing with whatever, especially this year. We’re used to getting away for a week or so. But I can’t tell you how sick of each other we are after a week in a hotel. … A week’s not the daunting thing. It’s the month of December that guys get a little overwhelmed with.”

Shanahan said the team looked into the possibility of practicing in the Bay Area outside of Santa Clara County and flying to Arizona for the games. But they couldn’t find a suitable location close enough to make it worth it and opted to go on the road for three weeks instead.

The Niners fly out this afternoon and begin a normal week of practice Thursday at the site where the Arizona Cardinals held training camp in Glendale. The team will stay in a hotel near the practice facility and stadium before playing “home” games against Buffalo on Dec. 7 and Washington on Dec. 13.

San Francisco then plans to practice there again the following week before playing at Dallas on Dec. 20.