NAIROBI, Kenya — More than 100,000 children in Ethiopia’s embattled Tigray region could face the most extreme and life-threatening form of malnutrition in the next year, the United Nations children’s agency warned on Friday, as humanitarian aid remains blocked from the region of some 6 million people.

The U.N. estimate, a tenfold increase over the usual caseload in Tigray, is based on “essentially the scenario we’re seeing now, in which the conflict escalates and food access is restricted,” Marixie Mercado with UNICEF’s emergency response team told The Associated Press.

The warning comes as high-level officials from the U.N. and United States visit Ethiopia over the next several days to press the government to lift what the U.S. has described as a “siege” of Tigray and as some 200 food-laden U.N. trucks are stuck on the only remaining road into the region.