In this image made from UNTV video, Tommy Esang Remengesau Jr., President of Palau, speaks in a pre-recorded message which was played during the 75th session of the United Nations General Assembly, Wednesday, Sept. 23, 2020, at UN headquarters in New York. The U.N.'s first virtual meeting of world leaders started Tuesday with pre-recorded speeches from some of the planet's biggest powers, kept at home by the coronavirus pandemic that will likely be a dominant theme at their video gathering this year. (UNTV via AP)

JOHANNESBURG (AP) — If the United Nations was created from the ashes of World War II, what will be born from the global crisis of COVID-19?

Many world leaders at this week’s virtual U.N. summit hope it will be a vaccine made available and affordable to all countries, rich and poor. But with the U.S., China and Russia opting out of a collaborative effort to develop and distribute a vaccine, and some rich nations striking deals with pharmaceutical companies to secure millions of potential doses, the U.N. pleas are plentiful but likely in vain.

“Are people to be left to die?” Honduran President Juan Orlando Hernández, a COVID-19 survivor, said of the uncertain way forward.

More than 150 countries have joined COVAX, in which richer countries agree to buy into potential vaccines and help finance access for poorer ones. But the absence of Washington, Beijing and Moscow means the response to a health crisis unlike any other in the U.N.’s 75 years is short of truly being global. Instead, the three powers have made vague pledges of sharing any vaccine they develop, likely after helping their own citizens first.

This week’s U.N. gathering could serve as a wake-up call, said Gayle Smith, president of the ONE Campaign, a nonprofit fighting preventable disease that’s developing scorecards to measure how the world’s most powerful nations are contributing to vaccine equity.

“It’s not enough for only some G20 countries to realize that an equitable vaccine is the key to ending this virus and reopening the global economy,” she said.

With weeks remaining before a deadline for countries to join COVAX, which is co-led by the U.N.’s World Health Organization, many heads of state are using the U.N. meeting as a high-profile chance to wheedle, persuade and even shame.

Ghana’s president, Nana Akufo-Addo, pointed out the illusory nature of borders and wealth: “The virus has taught us that we are all at risk, and there is no special protection for the rich or a particular class.”

The president of the COVID-free Pacific island nation of Palau, Tommy Remengesau Jr., warned against selfishness: “Vaccine hoarding will harm us all.”

And Rwanda’s president, Paul Kagame, appealed to the universal desire for a return to normal: “Ensuring equitable access to vaccines, therapeutics and diagnostics will speed up the end of the pandemic for everyone.”

Just two days into nearly 200 speeches by world leaders, it was clear the urgent need for a vaccine would be mentioned by almost everyone.

Considering the mind-popping challenges ahead, that’s no surprise.

“We’ve never dealt with a situation where 7.8 billion people in the world are needing a vaccine at almost the same time,” John Nkengasong, head of the Africa Centers for Disease Control and Prevention, said this month.

That has led to difficult questions: Who will get vaccine doses first? Who is making private deals to get them? This week’s speeches make clear that such questions have existential meaning.

The vaccine quest must not be a “purely mercantile act,” Iraq said. Nor “an issue of competition,” Turkey said.

“We must take the politics out of the vaccine,” Kazakhstan said. “We need true globalization of compassion,” Slovakia said.