To Your Good Health: Low-risk estradiol treatment comes with an FDA-boxed warning
DEAR DR. ROACH: I'm a 70-year-old woman who has suffered with vaginal dryness ever since I went through menopause. My doctor has prescribed a hormone cream, estradiol 0.01%, to help with the symptoms. The side effects and warnings are worrisome, even though my doctor assures me that it's safe to use. I value your opinion and would appreciate your thoughts. -- K.C. ANSWER: The Food and Drug Administration requires boxed warnings, which are the highest level of concern, on systemic estrogen such as pills. Until November 2025, the same warnings existed on topical treatments such as creams ...