TEMPE, Ariz. — Brandon Ruiz hit a 28-yard field goal as time expired, Manny Wilkins threw for 380 yards and a touchdown, and Arizona State rallied to beat No. 15 Michigan State 16-13 on Saturday night.

Arizona State (2-0) got the Herm Edwards era off to a rousing start with a 49-7 rout of UTSA in its opener. Faced with a bigger challenge, the Sun Devils never flinched, scoring 13 points in the fourth quarter to knock off the Spartans.

Wilkins hit N’Keal Harry on a tying 27-yard pass early in the fourth quarter, then orchestrated the last drive to set up Ruiz’s winning kick. The Sun Devils are 10-0 against Big Ten teams in Tempe.

Michigan State (1-1) had a hard time shaking Utah State to win its opener by seven. The Spartans had a similar problem with Arizona State after three drives inside the Sun Devils 10 resulted in two field goals and an interception.

Brian Lewerke, who played at nearby Pinnacle High School, threw for 314 yards and a touchdown for the Spartans, who are 1-13 in regular-season games out West.

Michigan State had some success with its ball-control offense in the first half, twice driving inside Arizona State’s 5-yard line. The Spartans came away with three points.